South West Thames Kidney Fund

Supporting Research into Kidney Disease and Diabetes

Funding > Research > Cure

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about your kidneys

Kidneys are bean shaped organs, each about the size of a fist. They are located just above waist level in your back, on the back wall of the abdominal cavity, either side of your spine.

 

Your kidneys have several important functions. They produce urine; filter waste from your blood; produce hormones, balance your body fluids and salts; and adjust levels of minerals and other chemicals so that your body can work properly.

 

Your body takes all the nutrients it needs from anything you eat or drink. What is left is waste. Some of this waste, as well as natural waste from your body’s metabolism, ends up in the blood and needs to be removed. This is where the kidneys come in.

 

HOW YOUR KIDNEYS WORK

 

One of the main functions of the kidney is to act as a filter. The kidney is made up of tiny filters called nephrons.  The average nephron number is approximately 900,000 to 1 million per kidney with numbers for individual kidneys range from approximately 200,000 to >2.5 million. Each nephron is made up of a glomerulus and tubule.

 

The glomerulus acts as a relatively crude filter retaining the larger constituents of blood, such as cells and large molecules.  Water and small molecules pass through the glomerulus and into the tubule. However, if all the water and small molecules were allowed to leave our blood we would quickly become dehydrated. So, before the kidney excretes the waste products as urine, the tubules reabsorb most of the water and other small but important constituents of the blood that have passed through the glomerulus.  Only then does the kidney excrete the remaining liquid waste as urine.

 

Healthy kidneys work 24 hours a day 7 days a week to clean the blood. Each day approximately180 litresof blood are filtered through the kidneys.

 

The kidneys are usually very effective at their job and it is often only once they have lost 75-80% of their function that symptoms are noticed.

 

KIDNEY DISEASE RESEARCH

 

Chronic kidney disease (CKD) is caused by gradual loss of kidney function and may lead to permanent kidney failure, at which point dialysis or a kidney transplant will be needed.

 

The South West Thames Kidney Fund supports the research into kidney disease and diabetes at the South West Thames Institute for Renal Research based at St Helier Hospital, Carshalton, Surrey. The aim of the South West Thames Institute for Renal Research is:

 

  • To improve the quality of patients’ lives by finding the causes of kidney failure
  • To slow down the process of kidney failure
  • To improve the treatments and ultimately find a cure

References
Benner & Rector’s the Kidney.  Barry M Brenner Saunders;  9th Edition, 2012
http://www.us.elsevierhealth.com/nephrology/brenner-and-rector-the-kidney-expert-consult/9781416061939/ 

 

NDT Plus Carmine Zoccali, Anneke Kramer and Kitty J Jager 2010 Chronic kidney disease and en-stage renal disease
http://ckj.oxfordjournals.org./content/3/3/213.full.pdf+html 

 

www.nhs.uk/Conditions/Kidney-disease-chronic/

 

About chronic kidney disease:  A guide for patients and their families.
National Kidney Foundation.  http://www.kidney.org

 

Human nephron number:  implications for health and disease.
Bertram JF1, Douglas-Denton RN, Diouf B, Hughson MD, Hoy WE
http://www.ncbi.nlm.giv/pubmed/?term=21604189 

 

PLEASE SUPPORT KIDNEY DISEASE RESEARCH

 

15 January 2015; Vs 4